Amivantamab (Genetical Recombination)



Amivantamab is a recombinant bispecific human IgG1 monoclonal antibody against human epidermal growth factor receptor (EGFR) and human hepatocyte growth factor receptor (MET) whose amino acid residues at positions 413 in the anti-EGFR-H-chain and 411 in the anti-MET-H-chain are substituted by Leu and Arg, respectively. Amivantamab is produced in Chinese hamster ovary cells that express antibody with low-fucosylated glycans. Amivantamab is a glycoprotein (molecular weight: ca. 148,000) composed of an anti-EGFR-H-chain (γ1-chain) consisting of 455 amino acid residues, an anti-MET-H-chain (γ1-chain) consisting of 449 amino acid residues, an anti-EGFR-L-chain (κ-chain) consisting of 214 amino acid residues and an anti-MET-L-chain (κ-chain) consisting of 214 amino acid residues each.

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