Andexanet Alfa (Genetical Recombination)



Andexanet Alfa is a recombinant activated human blood coagulation factor X (FXa) analog whose L-chain corresponds to amino acids at positions 1 – 5 and 40 – 139 of L-chain of FXa, and whose amino acid residue at position 185 of H-chain is substituted by Ala. Andexanet Alfa is produced in Chinese hamster ovary cells. Andexanet Alfa is a glycoprotein (molecular weight; ca. 41,000) composed of an L-chain consisting of 105 amino acid residues and an H-chain consisting of 254 amino acid residues.

[1262449-58-0]