Anifrolumab (Genetical Recombination)



Anifrolumab is a recombinant human IgG1 monoclonal antibody against type I interferon receptor 1 (interferon alpha, beta and omega receptor 1), whose amino acid residues at position 234, 235 and 331 are substituted by Phe, Glu and Ser, respectively, in the H-chain. Anifrolumab is produced in mouse myeloma (NS0) cells. Anifrolumab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ1-chains) consisting of 447 amino acid residues each and 2 L-chains (κ-chains) consisting of 215 amino acid residues each.

[1326232-46-5]