Asfotase Alfa (Genetical Recombination)



Asfotase alfa is a recombinant fusion glycoprotein corresponding to a catalytic domain of human tissue non-specific alkaline phosphatase at positions 1 – 485, Fc domain of human Ig G1 at positions 488 – 714, and 10 residues of Asp are attached to the C-terminus. Asfotase alfa is produced in Chinese hamster ovary cells. Asfotase alfa is a glycoprotein (molecular weight: ca. 180,000) composed of 2 subunits consisting of 726 amino acid residues each.

[1174277-80-5]