Axatilimab (Genetical Recombination)



Axatilimab is a recombinant anti-colony stimulating factor 1 receptor (CSF-1R) monoclonal antibody whose complementarity-determining regions are derived from rat antibody and other regions are derived from human IgG4. In the H-chain, the amino acid residue is substituted at 1 position (S234P). Axatilimab is produced in CHO cells. Axatilimab is a glycoprotein (molecular weight: ca. 150,000) composed of 2 H-chains (γ4-chains) consisting of 453 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[2155851-88-8]