Belantamab Mafodotin (Genetical Recombination)



Belantamab Mafodotin is an antibody-drug-conjugate (molecular weight: ca. 152,000) consisting of Mafodotin (N-((2R,3R)-3-{(2S)-1-[(3R,4S,5S)-4-({N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-N-methyl-L-valyl-L-valyl}methylamino)-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl}-3-methoxy-2-methylpropanoyl)-L-phenylalanine (C₄₉H₇₆N₆O₁₁; molecular weight: 925.16)), which is composed of monomethylauristatin F and linker, attached to an average of 4 Cys residues of a recombinant monoclonal antibody. The monoclonal antibody moiety is an anti-human B cell manutation antigen (BCMA) monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG1 and produced in glycoprotein 6-α-L-fucosyltransferase-deficient Chinese hamster ovary cells. The protein moiety is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

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