Bintrafusp Alfa (Genetical Recombination)



Bintrafusp Alfa is a recombinant fusion glycoprotein (molecular weight: ca. 177,000) composed of human anti-human PD-L1 monoclonal antibody and extracellular domain of the human TGF-β type II receptor. Bintrafusp Alfa is produced in Chinese hamster ovary cells. Bintrafusp Alfa is composed of 2 A-chains consisting of 216 amino acid residues each and 2 B-chains consisting of 607 amino acid residues each. The A-chain is the L-chain (λ-chain) of the anti-human PD-L1 antibody, and the amino acid residues at positions 1-449, 450-471, and 472-607 in the B-chains are composed of the H-chain (γ1-chain) of the anti-human PD-L1 antibody, a linker, and extracellular domain of the human TGF-β type II receptor, respectively.

[1918149-01-5]