Crovalimab (Genetical Recombination)



Crovalimab is a recombinant anti-human complement C5 monoclonal antibody, the complementarity-determining regions of which are derived from rabbit antibody and other regions are derived from human IgG1. In the H-chain, the amino acid residues at positions 241, 242, 245, 333, 336, 337, 434, 440, 444 and 446 are substituted by Arg, Arg, Lys, Gly, Ser, Ser, Leu, Ala, Arg and Glu, respectively, and Gly and Lys at the C-terminus are deleted. Crovalimab is produced in Chinese hamster ovary cells. Crovalimab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ1-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 217 amino acid residues each.

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