Damoctocog Alfa Pegol (Genetical Recombination)



Damoctocog Alfa Pegol is a recombinant human blood coagulation factor VIII analogue (molecular weight: ca. 234,000) whose protein moiety corresponds to amino acids 1 - 754 and 1649 - 2332 of human blood coagulation factor VIII. Damoctocog Alfa Pegol is composed of an H chain consisting of 754 amino acid residues and an L chain consisting of 684 amino acid residues, and a polyethylene glycol polymer (average molecular weight: ca. 60,000) is attached to amino acid residue of the L chain at position 156 which was substituted by Cys via linker. The glycoprotein is composed of 1438 amino acid residues and produced in Baby hamster kidney cells.

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