Denecimig (Genetical Recombination)



Denecimig is a recombinant bispecific monoclonal antibody against activated coagulation factor IX (FIXa) and coagulation factor X (FX), in which anti-FIXa H-chain and anti-FX H-chain are derived from human IgG4. In the anti-FIXa H-chain, one amino acid residue is substituted (S230P) and K449 at the C-terminus is deleted. In the anti-FX H-chain, three amino acid residues are substituted (S228P, F405L, R409K), and K447 at the C-terminus is deleted. Denecimig is produced in CHO cells. Denecimig is a glycoprotein (molecular weight: ca. 148,000) composed of an anti-FIXa H-chain (γ4-chain) consisting of 448 amino acid residues, an anti-FIXa L-chain (κ-chain) consisting of 214 amino acid residues, an anti-FX H-chain (γ4-chain) consisting of 446 amino acid residues and an anti-FX L-chain (κ-chain) consisting of 216 amino acid residues each.

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