Depemokimab (Genetical Recombination)



Depemokimab is a recombinant anti-interleukin-5 monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions are derived from human IgG1. In the H-chain, the amino acid residues are substituted at 3 positions (M254Y, S256T, T258E). Depemokimab is produced in CHO cells. Depemokimab is a glycoprotein (molecular weight: ca.149,000) composed of 2 H-chains (γ1-chains) consisting of 449 amino acid residues each and 2 L-chains (κ-chains) consisting of 220 amino acid residues each.

[2243274-14-6]