Domagrozumab (Genetical Recombination)



Domagrozumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human growth differentiation factor 8 (GDF-8) monoclonal antibody, human framework regions and human IgG1 constant regions, whose amino acid residues at positions 233, 234, and 236 in H-chains are substituted by Ala each. Domagrozumab is produced in Chinese hamster ovary cells. Domagrozumab is a glycoprotein (molecular weight: ca. 146,000) composed of 2 H-chains (γ1-chains) consisting of 446 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[1629605-31-7]