Donanemab (Genetical Recombination)



Donanemab is a recombinant anti-N-terminal pyroglutamyl amyloid beta peptides (3-x) monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions are derived from human IgG1. In the H-chain, K445 at the C-terminus is deleted. Donanemab is produced in CHO cells. Donanemab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ1-chains) consisting of 444 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.

[1931944-80-7]