Dulaglutide (Genetical Recombination)



Dulaglutide is a recombinant fusion glycoprotein containing modified human glucagon-like peptide-1 at positions 1 – 31 and modified Fc domain of human IgG4 at positions 48 – 275, and whose amino acid residues at positions 2, 16, 30, 57, 63 and 64 are substituted by Gly, Glu, Gly, Pro, Ala and Ala, respectively. Dulaglutide is produced in Chinese hamster ovary cells. Dulaglutide is a glycoprotein (molecular weight: ca. 63,000) composed of 2 subunits consisting of 275 amino acid residues each.

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