Dupilumab (Genetical Recombination)



Dupilumab is a recombinant human IgG4 monoclonal antibody against human interleukin-4 receptor α subunit, in which amino acid residues at position 233 in the H-chains are substituted by Pro . Dupilumab is produced in Chinese hamster ovary cells. Dupilumb is a glycoprotein (molecular weight: ca. 152,000) composed of 2 H-chains (γ4-chains) consisting of 452 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.

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