Efanesoctocog Alfa (Genetical Recombination)



Efanesoctocog Alfa is a recombinant Fc-human blood coagulation factor VIII (FVIII) -human von Willebrand factor (vWF) fusion glycoprotein (molecular weight: ca. 350,000) composed of an A-chain consisting of 1946 amino acid residues and a B-chain consisting of 883 amino acid residues. The amino acid residues at positions 1 – 745, 746 – 1033, 1034 – 1036, 1037 – 1720, and 1721 – 1946 of the A-chain correspond to amino acids residues at positions 1 – 745 of FVIII, unstructured polypeptide linker, peptide linker, amino acids residues at positions 1649 – 2332 of FVIII, and Fc domain of human IgG1 whose C terminal lysine residue is deleted. The amino acid residues at positions 1 – 477, 478 – 625, 626 – 657, and 658 – 883 of the B-chain correspond to amino acid residues at positions 742 – 1218 of vWF (C336A, C379A), unstructured polypeptide linker, amino acid residues at positions 626 – 657 of FVIII, and Fc domain of human IgG1 whose C terminal lysine residue is deleted. Efanesoctocog Alfa is produced in HEK293 cells.

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