Eftrenonacog Alfa (Genetical Recombination)



Eftrenonacog Alfa is a recombinant Fc-human blood coagulation factor IX (FIX) fusion glycoprotein (molecular weight: ca. 109,000) composed of an A-chain consisting of 642 amino acid residues and a B-chain consisting of 227 amino acid residues. Amino acids at positions 1415 of the A-chain correspond to FIX, and amino acids at positions 416642 of the A-chain and the B-chain correspond to Fc domain of human IgG1. Eftrenonacog Alfa is produced in a human embryonic kidney cell line.