Epcoritamab (Genetical Recombination)



Epcoritamab is a recombinant bispecific monoclonal antibody against CD3ε chain and CD20, which is composed of anti-CD3ε chain antibody whose variable regions are derived from mouse antibody and other regions are derived from human IgG1, and anti-CD20 antibody derived from human IgG1. In the anti-CD3ε-H-chain, the amino acid residues are substituted at 4 positions (L242F, L243E, D273A, F413L), and K455 at the C-terminus is deleted. In the anti-CD20-H-chain, the amino acid residues are substituted at 4 positions (L239F, L240E, D270A, K414R), and K452 at the C-terminus is deleted. Epcoritamab is produced in CHO cells. Epcoritamab is a glycoprotein (molecular weight: ca. 149,000) composed of an anti-CD3ε-H-chain (γ1-chain) consisting of 454 amino acid residues, an anti-CD3ε-L-chain (λ-chain) consisting of 215 amino acid residues, an anti-CD20-H-chain (γ1-chain) consisting of 451 amino acid residues, and an anti-CD20-L-chain (κ-chain) consisting of 214 amino acid residues.

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