Etentamig (Genetical Recombination)



Etentamig is a recombinant trivalent bispecific monoclonal antibody against B-cell maturation antigen (BCMA) and CD3ε. In the anti-BCMA H-chain, the amino acid residues at positions 1 – 119 and 125 – 243 are both derived from variable region of anti-BCMA antibody H-chain, and other regions are derived from IgG4 whose amino acid residues are substituted at 6 positions (S253P, F259A, L260A, T391S, L393A, Y432V). The anti-CD3ε chain is derived from human IgG4 whose amino acid residues are substituted at 4 positions (S231P, F237A, L238A, T369W). Etentamig is produced in CHO cells. Etentamig is a glycoprotein (molecular weight: ca. 126,000) composed of an anti-BCMA H-chain (γ4-chain) consisting of 472 amino acid residues, an anti-CD3ε H-chain (γ4-chain) consisting of 450 amino acid residues, and an anti-CD3ε L-chain (κ-chain) consisting of 214 amino acid residues.

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