Faricimab (Genetical Recombination)



Faricimab is a recombinant bispecific humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human vascular endothelial growth factor A (VEGF-A) antibody and human anti-human angiopoietin 2 (Ang2), framework regions and human IgG1 constant regions in which the anti-Ang2, CL domain in L-chain and CH1 domain in H-chain are exchanged each other. In the anti-VEGF-A-H-chain, the amino acid residues at position 240, 241, 259, 316, 335, 360, 372 and 441 are substituted by Ala, Ala, Ala, Ala, Gly, Cys, Trp and Ala, respectively. In the anti-Ang2-H-chain, the amino acid residues at position 250, 251, 269, 326, 345, 365, 382, 384, 423 and 451 are substituted by Ala, Ala, Ala, Ala, Gly, Cys, Ser, Ala, Val and Ala, respectively. Faricimab is produced in Chinese hamster ovary cells. Faricimab is a glycoprotein (molecular weight: ca. 149,000) composed of an anti-VEGF-A-H-chain (γ1-chain) consisting of 453 amino acid residues, an anti-VEGF-A-L-chain (κ-chain) consisting of 214 amino acid residues, an anti-Ang2-H-chain (γ1-κ-chain) consisting of 463 amino acid residues and an anti-Ang2-L-chain (λ-γ-chain) consisting of 213 amino acid residues each.

[1607793-29-2]