Fasinumab (Genetical Recombination)



Fasinumab is a recombinant human IgG4 monoclonal antibody against human nerve growth factor (NGF), whose amino acid residue at position 227 is substituted by Pro in the H-chain. Fasinumab is produced in Chinese hamster ovary cells. Fasinumab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ4-chains) consisting of 446 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

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