Feladilimab (Genetical Recombination)



Feladilimab is a recombinant anti-human inducible T-cell costimulator (ICOS) monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG4. In the H-chain, the amino acid residues at positions 229 and 236 are substituted by Pro and Glu, respectively. Feladilimab is produced in Chinese hamster ovary cells. Feladilimab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ4-chains) consisting of 448 amino acid residues each and 2 L-chains (κ-chains) consisting of 213 amino acid residues each.

[2252518-85-5]