Gefurulimab (Genetical Recombination)



Gefurulimab is a recombinant single-chain bivalent bispecific monoclonal antibody (VH-VH’) composed of a variable region of anti-human serum albumin (HSA) antibody at positions 1 – 123, linker at positions 124 – 138, and a variable region of anti-complement C5 antibody at positions 139 – 264. The complementarity-determining regions are derived from heavy-chain antibody from Lama glama, and the framework regions are mainly derived from human and partly from Lama glama. Gefurulimab is produced in CHO cells. Gefurulimab is a protein consisting of 264 amino acid residues.

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