Gosuranemab (Genetical Recombination)



Gosuranemab is a recombinant anti-human microtubule-associated protein tau monoclonal antibody having constant regions derived from human IgG4, whose amino acid residue at position 241 is substituted by Pro and C-terminal Lys is deleted in the H-chain. Gosuranemab is produced in Chinese hamster ovary cells. Gosuranemab is a glycoprotein (molecular weight: ca.145,000) composed of 2 H-chains (γ4-chains) consisting of 443 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.