Ifinatamab Deruxtecan (Genetical Recombination)



Ifinatamab Deruxtecan is an antibody-drug-conjugate (molecular weight: ca. 153,000) consisting of Deruxtecan ((3RS)-1-[(10S)-10-benzyl-1-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-1,6,9,12,15,18-hexaoxo-3-oxa-5,8,11,14,17-pentaazatricosan-23-yl]-2,5-dioxopyrrolidin-3-yl group (C₅₂H₅₇FN₉O₁₃; molecular weight: 1,035.06)), which is composed of camptothecin derivative and linker, attached to an average of four cysteine residues of a recombinant monoclonal antibody. The antibody moiety is a recombinant anti-CD276 monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG1 and produced in CHO cells. The protein moiety is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 452 amino acid residues each and 2 L-chains (κ-chains) consisting of 213 amino acid residues each.

[2484870-92-8]