Lanadelumab (Genetical Recombination)



Lanadelumab is a recombinant human IgG1 monoclonal antibody against human plasma kallikrein, whose C-terminal Lys is deleted in the H-chain. Lanadelumab is produced in Chinese hamster ovary cells. Lanadelumab is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 213 amino acid residues each.

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