Linvoseltamab (Genetical Recombination)



Linvoseltamab is a recombinant bispecific monoclonal antibody against B-cell maturation antigen (BCMA) and CD3ε chain, in which anti-BCMA H-chain and anti-CD3ε H-chain are derived from human IgG4. In the anti-BCMA H-chain, the amino acid residures at positions 233 and 238 – 240 are substituted by P from S and PVA from EFLG, respectively. In the anti-CD3ε H-chain, the amino acid residues at positions 232, 237 – 239, 438, 439 and 448 are substituted by P from S, PVA from EFLG, R from H, F from Y and P from L, respectively. Both of the L-chains are derived from human anti-CD3ε antibody L-chain. Linvoseltamab is produced in CHO cells. Linvoseltamab is a glycoprotein (molecular weight: ca. 149,000) composed of an anti-BCMA H-chain (γ4-chain) consisting of 451 amino acid residues, an anti-human CD3ε H-chain (γ4-chain) consisting of 450 amino acid residues and 2 L-chains (κ-chains) consisting of 215 amino acid residues each.

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