Luspatercept (Genetical Recombination)



Luspatercept is a recombinant fusion glycoprotein, whose amino acid residues at positions 1-107, 108-110 and 111-335 correspond to amino acid residues at positions 7-113 of modified human activin receptor type IIB (L55D; extracellular domain), a linker, and an Fc domain of human IgG1, respectively. Luspatercept is produced in CHO cells. Luspatercept is a glycoprotein (molecular weight: ca. 94,000) composed of 2 subunits consisting of 335 amino acid residues each.

[1373715-00-4]