Mepolizumab (Genetical Recombination)



Mepolizumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human interleukin-5 monoclonal antibody and framework regions and constant regions derived from human IgG1. Mepolizumab is produced in Chinese hamster ovary cells. Mepolizumab is a glycoprotein (molecular weight: ca.149,000) composed of 2 H-chains (γ1-chains) consisting of 449 amino acid residues each and 2 L-chains (κ-chains) consisting of 220 amino acid residues each.

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