Mirvetuximab Soravtansin (Genetical Recombination)



Mirvetuximab Soravtansine is an antibody-drug-conjugate (molecular weight: ca. 152,000) consisting of Soravtansine (3-[(5-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^10,14.0^3,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-methyl-2-oxoethyl]methylamino}-2-methyl-5-oxopentan-2-yl)disulfanyl]propylcarbonyl-1-sulfonic acid group (C₄₂H₅₉ClN₃O₁₄S₃; molecular weight: 961.58)), which is composed of maytansinoid DM4 and a 3-sulfanylpropylcarbonyl-1-sulfonic acid group linker, attached to an average of 3-4 Lysine residues of a recombinant monoclonal antibody. The antibody moiety is an anti-folate receptor α monoclonal antibody, the variable regions of which are derived from mouse antibody and other regions are derived from human IgG1 and C-terminal K448 is deleted. The antibody moiety is produced in CHO cells. The protein moiety is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 447 amino acid residues each and 2 L-chains (κ-chains) consisting of 218 amino acid residues each.

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