Nivolumab (Genetical Recombination)



Nivolumab is a recombinant human IgG4 monoclonal antibody against human PD-1, whose amino acid residue at position 221 in the H-chain is substituted by Pro. Nivolumab is produced in Chinese hamster ovary cells. Nivolumab is a glycoprotein (molecular weight: ca.145,000) composed of 2 H-chains (γ4-chains) consisting of 440 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

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