Obinutuzumab (Genetical Recombination)



Obinutuzumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human CD20 monoclonal antibody and framework regions and constant regions derived from human IgG1. Obinutuzumab is produced in Chinese hamster ovary cells transfected with antibody genes together with genes encoding β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase and mannosyl-oligosaccharide 1,3-1,6-α-mannosidase. Obinutuzumab is a glycoprotein (molecular weight: ca.148,000 – 150,000) composed of 2 H-chains (γ1-chains) consisting of 449 amino acid residues each and 2L-chains (κ-chains) consisting of 219 amino acid residues each.

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