Odronextamab (Genetical Recombination)



Odronextamab is a recombinant bispecific monoclonal antibody against CD20 and CD3ε chain, in which anti-CD20 H-chain and anti-CD3ε H-chain are derived from human IgG4. In the anti-CD20 H-chain, the amino acid residues at positions 235 and 240 – 242 are substituted by P from S and PVA from EFLG, respectively. In the anti-CD3ε H-chain, the amino acid residues at positions 231, 236 – 238, 437 and 438 are substituted by P from S, PVA from EFLG, R from H and F from Y, respectively. Both of the L-chains are derived from anti-CD3ε L-chain variable region and constant region of human antibody L-chain. Odronextamab is produced in CHO cells. Odronextamab is a glycoprotein (molecular weight: ca. 148,000) composed of an anti-CD20 H-chain (γ4-chain) consisting of 453 amino acid residues, an anti-human CD3ε H-chain (γ4-chain) consisting of 449 amino acid residues and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[1801338-64-6]