Onartuzumab (Genetical Recombination)



Onartuzumab is a recombinant monovalent humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human hepatocyte growth factor receptor antibody and framework regions and constant regions derived from human IgG1. Onartuzumab is a protein composed of an L-chain (κ-chain) consisting of 220 amino acid residues, an H-chain (γ1-chain) consisting of 449 amino acid residues and an H-chain fragment consisting of 227 amino acid residues, which corresponds to amino acid residues 223—449 of an H-chain. Amino acid residues of an H-chain at positions 358, 360, 368, 370 and 409 are substituted by Glu, Met, Ser, Ala and Val, respectively. Amino acid residues of an H-chain fragment at positions 136, 138 and 146 are substituted by Glu, Met and Trp, respectively.

[1133766-06-9]