Pegaspargase



Pegaspargase is an analogue of L-asparaginase (EC 3.5.1.1), which is produced by Escherichia coli, and to which an average of 7 methoxy polyethylene glycol polymers (molecular weight: ca. 5,000) per subunit are bound via a linker (major pegylation sites: Leu1 and Lys residues). Pegaspargase is a pegylated protein (molecular weight: ca. 280,000) composed of 4 subunits consisting of 326 amino acid residues each.

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