Pegvaliase (Genetical Recombination)



Pegvaliase is a recombinant Anabaena variabilis phenylalanine ammonia-lyase (EC 4.3.1.24) analogue, whose amino acid residues at positions 503 and 565 are substituted by Ser, respectively, and in which methylidene imidazolone is formed from Ala-Ser-Gly at positions 167-169, in addition, to which an average of approximately 9 methoxy polyethylene glycol polymers (molecular weight: ca. 20,000) per subunit are bound via carbonyl groups (major pegylation sites: Lys residues). Pegvaliase is a pegylated protein (molecular weight: ca. 917,000) composed of 4 subunits consisting of 567 amino acid residues each.

[1585984-95-7]