Pembrolizumab (Genetical Recombination)



Pembrolizumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human PD-1 monoclonal antibody and framework regions and constant regions derived from human IgG4, whose amino acid residue at position 228 in the H-chain is substituted by Pro. Pembrolizumab is produced in Chinese hamster ovary cells. Pembrolizumab is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ4-chains) consisting of 447 amino acid residues each and 2 L-chains (κ-chains) consisting of 218 amino acid residues each.

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