Ravulizumab (Genetical Recombination)



Ravulizumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human complement C5 monoclonal antibody, human framework regions and human IgG constant regions. The L-chain constant region is derived from a human κ-chain. The CH1, hinge and a part of CH2 regions of the H-chain constant regions are derived from human IgG2 (γ2-chain) and the rest of CH2 and CH3 regions are derived from human IgG4 (γ4-chain). In the H-chain, Met429 and Asn435 are substituted by Leu and Ser, respectively. Ravulizumab is produced in Chinese hamster ovary cells. Ravulizumab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains consisting of 448 amino acid residues each and 2 L-chains consisting of 214 amino acid residues each.

[1803171-55-2]