Risankizumab (Genetical Recombination)



Risankizumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human interleukin-23 α subunit (p19) monoclonal antibody, human framework regions and human IgG1 constant regions, whose amino acid residues at position 237 and 238 in the H-chains are substituted by Ala each and C-terminus Lys is deleted in the H-chains. Risankizumab is produced in Chinese hamster ovary cells. Risankizumab is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 449 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[1612838-76-2]