Rozanolixizumab (Genetical Recombination)



Rozanolixizumab is a recombinant humanized and chimeric anti-human neonatal Fc receptor (FcRn) monoclonal antibody in which the H-chains are composed of complementarity-determining regions derived from rat anti-FcRn monoclonal antibody, human framework regions and a human IgG4 constant regions and the L-chains are composed of variable regions derived from rat anti-FcRn antibody and human IgG constant regions. The amino acid residue at position 225 in the H-chain is substituted by Pro. Rozanolixizumab is produced in Chinese hamster ovary cells. Rozanolixizumab is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ4-chains) consisting of 444 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.

[1584645-37-3]