Sabatolimab (Genetical Recombination)



Sabatolimab is a recombinant anti-human T-cell immunoglobulin mucin family member 3 (TIM-3) monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG4. In the H-chain, the amino acid residue at position 226 is substituted by Pro, and Lys at the C-terminus is deleted. Sabatolimab is produced in Chinese hamster ovary cells. Sabatolimab is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ4-chains) consisting of 444 amino acid residues each and 2 L-chains (κ-chains) consisting of 218 amino acid residues each.

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