Sarilumab (Genetical Recombination)



Sarilumab is a recombinant human IgG1 monoclonal antibody against human interleukin-6 receptor α subunit. Sarilumab is produced in Chinese hamster ovary cells. Sarilumab is a glycoprotein (molecular weight: ca. 150,000) composed of 2 H-chains (γ1-chains) consisting of 446 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

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