Sigvotatug Vedotin (Genetical Recombination)



Sigvotatug Vedotin is an antibody-drug-conjugate (molecular weight: ca. 152,000) consisting of Vedotin ((3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl group (C₆₈H₁₀₆N₁₁O₁₅; molecular weight: 1,317.63)), which is composed of monomethyl auristatin E and linker, attached to an average of four cysteine residues of the recombinant monoclonal antibody. The antibody moiety is a recombinant anti-β6 integrin monoclonal antibody whose complementaritydetermining regions are derived from mouse antibody, and other regions are derived from human IgG1. The antibody moiety is produced in CHO cells. The protein moiety is a glycoprotein (molecular weight: ca. 147,000) composed of 2 H-chains (γ1-chains) consisting of 446 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[2764774-91-4]