Sutimlimab (Genetical Recombination)



Sutimlimab is a recombinant anti-human complement C1s (C1s) monoclonal antibody in which the H-chains are composed of complementarity-determining regions derived from mouse anti-C1s antibody, human framework regions and human IgG4 constant regions and the L-chains are composed of variable regions derived from mouse anti-C1s antibody and constant regions of human κ-chain. In the H-chain, amino acid residues at positions 226 and 233 are substituted by Pro and Glu, respectively. Sutimlimab is produced in Chinese hamster ovary cells. Sutimlimab is a glycoprotein (molecular weight: ca. 145,000) composed of 2 H-chains (γ4-chains) consisting of 445 amino acid residues each and 2 L-chains (κ-chains) consisting of 216 amino acid residues each.

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