Tafasitamab (Genetical Recombination)



Tafasitamab is a recombinant anti-CD19 monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions are derived from human IgG1 and IgG2. In the H-chain, the amino acid residues at positions 122 – 240 correspond to CH1 and a part of CH2 domain of human IgG1, and 241 – 451 correspond to the rest of CH2 and CH3 domain of human IgG2, and amino acid residues are substituted at 3 positions (S243D, G331A, I336E). Tafasitamab is produced in CHO cells. Tafasitamab is a glycoprotein (molecular weight: ca. 150,000) composed of 2 H-chains (γ1 and γ2-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.

[1422527-84-1]