Talquetamab (Genetical Recombination)



Talquetamab is a recombinant bispecific monoclonal antibody against G protein-coupled receptor class C group 5 member D (GPRC5D) and CD3ε chain, in which anti-GPRC5D H-chain and anti-CD3ε H-chain are derived from human IgG4. In the anti-GPRC5D H-chain, the amino acid residues are substituted at 3 positions (S226P, F232A, L233A). In the anti-CD3ε H-chain, the amino acid residues are substituted at 5 positions (S233P, F239A, L240A, F410L, R414K). Talquetamab is produced in CHO cells. Talquetamab is a glycoprotein (molecular weight: ca. 147,000) composed of an anti-GPRC5D H-chain (γ4-chain) consisting of 445 amino acid residues, an anti-GPRC5D L-chain (κ-chain) consisting of 214 amino acid residues, an anti-CD3ε H-chain (γ4-chain) consisting of 452 amino acid residues and an anti-CD3ε L-chain (λ-chain) consisting of 215 amino acid residues each.

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