Tanezumab (Genetical Recombination)



Tanezumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human nerve growth factor (NGF) βsubunit monoclonal antibody, human framework regions and human IgG2 constant regions, whose amino acid residues at position 330 and 331 are substituted by Ser each in the H-chain. Tanezumab is produced in Chinese hamster ovary cells. Tanezumab is a glycoprotein (molecular weight: ca.148,000) composed of 2 H-chains (γ2-chains) consisting of 447 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

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