Tarlatamab (Genetical Recombination)



Tarlatamab is a recombinant single-chain bivalent bispecific monoclonal antibody (scFv-scFv’-scFc) composed of anti-delta-like ligand 3 (DLL3) antibody variable region (scFv) at positions 1 – 241, anti-CD3ε antibody variable region (scFv’) at positions 248 – 496, and single-chain Fc domain (scFc) in which human IgG1 hinge, CH2 and CH3 regions are connected via a linker with human IgG1 hinge, CH2 and CH3 regions at positions 501 – 982. In the scFc, amino acid residues are substituted at 6 positions (R572C, N577G, V582C, R827C, N832G, V837C). Tarlatamab is produced in CHO cells. Tarlatamab is a protein consisting of 982 amino acid residues.

[2307488-83-9]