Teclistamab (Genetical Recombination)



Teclistamab is a recombinant bispecific monoclonal antibody against B-cell maturation antigen (BCMA) and CD3ε chain, in which anti-BCMA H-chain and anti-CD3ε H-chain are derived from human IgG4. In the anti-BCMA H-chain, the amino acid residues are substituted at 3 positions (S229P, F235A, L236A). In the anti-CD3ε H-chain, the amino acid residues are substituted at 5 positions (S233P, F239A, L240A, F410L, R414K). Teclistamab is produced in CHO cells. Teclistamab is a glycoprotein (molecular weight: ca. 146,000) composed of an anti-BCMA H-chain (γ4-chain) consisting of 448 amino acid residues, an anti-BCMA L-chain (λ-chain) consisting of 214 amino acid residues, an anti-CD3ε H-chain (γ4-chain) consisting of 452 amino acid residues and an anti-CD3ε L-chain (λ-chain) consisting of 215 amino acid residues each.

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