Telisotuzumab Vedotin (Genetical Recombination)



Telisotuzumab Vedotin is an antibody-drug-conjugate (molecular weight: ca. 152,000) consisting of Vedotin ((3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl group (C₆₈H₁₀₆N₁₁O₁₅; molecular weight: 1,317.63)), which is composed of monomethyl auristatin E and linker, mainly attached to two or four cysteine residues of the recombinant monoclonal antibody. The antibody moiety is a recombinant anti-hepatocyte growth factor receptor monoclonal antibody whose complementarity-determining regions are derived from mouse antibody, and other regions are derived from human IgG1 with K222 and T225 (Eu numbering) in the H-chains deleted. In the antibody, the amino acid residue in the H-chain is substituted at 1 position (T223C), and K446 at the C-terminus is deleted. The antibody moiety is produced in CHO cells. The protein moiety is a glycoprotein (molecular weight: ca. 148,000) composed of 2 H-chains (γ1-chains) consisting of 445 amino acid residues each and 2 L-chains (κ-chains) consisting of 218 amino acid residues each.

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